The Enid News and Eagle, Enid, OK

National and world

March 3, 2013

Scientists: Baby born with HIV apparently cured

WASHINGTON — A baby born with the virus that causes AIDS appears to have been cured, scientists announced Sunday, describing the case of a child from Mississippi who’s now 2 1/2 and has been off medication for about a year with no signs of infection.

There’s no guarantee the child will remain healthy, although sophisticated testing uncovered just traces of the virus’ genetic material still lingering. If so, it would mark only the world’s second reported cure.

Specialists say Sunday’s announcement, at a major AIDS meeting in Atlanta, offers promising clues for efforts to eliminate HIV infection in children, especially in AIDS-plagued African countries where too many babies are born with the virus.

“You could call this about as close to a cure, if not a cure, that we’ve seen,” Dr. Anthony Fauci of the National Institutes of Health, who is familiar with the findings, told The Associated Press.

A doctor gave this baby faster and stronger treatment than is usual, starting a three-drug infusion within 30 hours of birth. That was before tests confirmed the infant was infected and not just at risk from a mother whose HIV wasn’t diagnosed until she was in labor.

“I just felt like this baby was at higher-than-normal risk, and deserved our best shot,” Dr. Hannah Gay, a pediatric HIV specialist at the University of Mississippi, said in an interview.

That fast action apparently knocked out HIV in the baby’s blood before it could form hideouts in the body. Those so-called reservoirs of dormant cells usually rapidly reinfect anyone who stops medication, said Dr. Deborah Persaud of Johns Hopkins Children’s Center. She led the investigation that deemed the child “functionally cured,” meaning in long-term remission even if all traces of the virus haven’t been completely eradicated.

Next, Persaud’s team is planning a study to try to prove that, with more aggressive treatment of other high-risk babies. “Maybe we’ll be able to block this reservoir seeding,” Persaud said.

No one should stop anti-AIDS drugs as a result of this case, Fauci cautioned.

But “it opens up a lot of doors” to research if other children can be helped, he said. “It makes perfect sense what happened.”

Better than treatment is to prevent babies from being born with HIV in the first place.  

About 300,000 children were born with HIV in 2011, mostly in poor countries where only about 60 percent of infected pregnant women get treatment that can keep them from passing the virus to their babies. In the U.S., such births are very rare because HIV testing and treatment long have been part of prenatal care.

“We can’t promise to cure babies who are infected. We can promise to prevent the vast majority of transmissions if the moms are tested during every pregnancy,” Gay stressed.

The only other person considered cured of the AIDS virus underwent a very different and risky kind of treatment — a bone marrow transplant from a special donor, one of the rare people who is naturally resistant to HIV. Timothy Ray Brown of San Francisco has not needed HIV medications in the five years since that transplant.

The Mississippi case shows “there may be different cures for different populations of HIV-infected people,” said Dr. Rowena Johnston of amFAR, the Foundation for AIDS Research. That group funded Persaud’s team to explore possible cases of pediatric cures.

It also suggests that scientists should look back at other children who’ve been treated since shortly after birth, including some reports of possible cures in the late 1990s that were dismissed at the time, said Dr. Steven Deeks of the University of California, San Francisco, who also has seen the findings.

“This will likely inspire the field, make people more optimistic that this is possible,” he said.

In the Mississippi case, the mother had had no prenatal care when she came to a rural emergency room in advanced labor. A rapid test detected HIV. In such cases, doctors typically give the newborn low-dose medication in hopes of preventing HIV from taking root. But the small hospital didn’t have the proper liquid kind, and sent the infant to Gay’s medical center. She gave the baby higher treatment-level doses.

The child responded well through age 18 months, when the family temporarily quit returning and stopped treatment, researchers said. When they returned several months later, remarkably, Gay’s standard tests detected no virus in the child’s blood.

Ten months after treatment stopped, a battery of super-sensitive tests at half a dozen laboratories found no sign of the virus’ return. There were only some remnants of genetic material that don’t appear able to replicate, Persaud said.

In Mississippi, Gay gives the child a check-up every few months: “I just check for the virus and keep praying that it stays gone.”

The mother’s HIV is being controlled with medication and she is “quite excited for her child,” Gay added.

1
Text Only
National and world
  • Taiwan web.jpg Gas explosions kill 24, injure 271 in Taiwan

    The fires were believed caused by a leak of propene, a petrochemical material not intended for public use, but the source of the gas was not immediately clear, officials said.

    July 31, 2014 1 Photo

  • Congress web.jpg Congress races to finish VA, highway bills

    House Speaker John Boehner accused Democrats of pursuing a “nutso scheme” of trying to seize on the border crisis to try and grant a path to citizenship to millions of immigrants living in the country illegally.

    July 31, 2014 1 Photo

  • Illinois Unemployment_Hass.jpg As U.S. job market strengthens, many don't feel it

    "If the economy is getting better, I'm not sure for whom. It certainly hasn't trickled down to me." — Douglas Hunter, who earned $14 an hour before the Great Recession and now works three days a week for $9.25 an hour, mopping floors and fixing fryers at McDonald's.

    July 31, 2014 1 Photo

  • House Obama Lawsuit.jpg Republican-led House approves lawsuit against President Obama

    Just a day before lawmakers were to begin a five-week summer recess, debate over the proposed lawsuit underscored the harshly partisan tone that has dominated the current Congress almost from its start in January 2013.

    July 31, 2014 1 Photo

  • Russia Putin web.jpg Sanctions could damage Russia

    The sanctions go further than earlier penalties — which had largely targeted individuals — by broadly limiting the trade of weapons and of technology that can be used in the oil and military industries. The EU also put its capital markets off-limits to Russian state-owned banks.

    July 31, 2014 1 Photo

  • Mideast Libya web.jpg Thousands flee to Tunisia to escape Libya fighting

    Many diplomats, including the U.S. ambassador, have pulled out of the country. With the interim government paralyzed, the fighting threatens the planned opening session of the newly elected parliament on Aug. 4.

    July 30, 2014 1 Photo

  • Obit Robert Drew web.jpg Cinema verite documentarian Robert Drew dies

    Starting in 1960 with “Primary,” Drew produced and sometimes directed a series of television documentaries that took advantage of such innovations as light hand-held cameras that recorded sound and pictures.

    July 30, 2014 1 Photo

  • Obama Ukraine Russia_Hass_W.jpg GOP-led House approves lawsuit against Obama

    The suit will contend that Obama has exceeded his constitutional powers in the way he has enforced the 2010 health care law.

    July 30, 2014 1 Photo

  • Texas: Gay-marriage ban best for children

    Texas’ ban on same-sex marriage allows the state to promote the birth and upbringing of children in “stable, lasting relationships,” the state’s attorney general argued Tuesday while asking a federal appeals court to reinstate the ban.

    July 30, 2014 1 Story

  • OKCupid, Facebook not alone in studying consumers

    Dating is hard.

    July 29, 2014

Featured Ads