Early in the second quarter, Lewis had a deflected pass in his grasp with designs of taking it into the end zone. But he dropped the ball, and many in the sellout crowd uttered a collective groan.
Upon being reminded of the drop, Lewis chuckled and said, "I'll never live that one down. I'm going to put that one on the brace because I tried to put my arm up but the brace wouldn't come up."
He wanted to remove the brace during the game, but thought better of it.
"I didn't feel pain," Lewis said. "I didn't hurt it one time."
Baltimore will next travel to Denver to face the top-seeded Broncos on Saturday.
There was some question as to how long Lewis would last in his first game action in three months. But the aged warrior appeared as fresh as the day he played his first game back in 1996.
"I thought he played exceptionally well," Harbaugh said. "It's always funny to hear people say, 'Well, he's not the same that was 10 years ago.' Well, who is?"
Lewis may have lost a step over the past decade, but he's still good enough to lead a playoff team in tackles. And to some, it was as if Lewis was 27 again.
"He was himself. He was the same guy you've seen for the last 17 years," teammate Cary Williams said. "He was the guy who led the huddle, just like always. We followed right behind him because we believe in him."
Ray Lewis fires up the crowd with his final dance at home stadium
With Lewis leading the way, the Ravens held the Colts without a touchdown. It was only the second time this season that Indianapolis failed to score in double figures.